Researchers find obesity can affect hair thinning, loss
Tokyo, Japan - September 27, ANI : Researchers have found the reason behind why obesity can lead to hair thinning.The findings of the study were published in the journal 'Nature'.They found that stem cells within hair follicles in mice given a high-fat diet behaved differently from those in mice with a standard diet. Inflammatory signals in the stem cells led to these differences, ultimately resulting in hair thinning and loss. These fascinating data shed light on the complicated link between obesity and organ dysfunction.It's well known that obesity is linked to the development of numerous diseases in humans. Heart disease, diabetes, and other ailments are extremely common in obese individuals. However, it's not fully clear how body organs specifically deteriorate and lose functionality from chronic obesity.In a recent study, a group of researchers from Tokyo Medical and Dental University, TMDU, used mouse model experiments to examine how a high-fat diet or genetically induced obesity can affect hair thinning and loss.The authors found that obesity can lead to depletion of hair follicle stem cells, HFSCs, through the induction of certain inflammatory signals, blocking hair follicle regeneration and ultimately resulting in loss of hair follicles.Normally, HFSCs self-renew every hair follicle cycle. This is part of the process that allows our hair to continuously grow back. As humans age, HFSCs fail to replenish themselves leading to fewer HFSCs and therefore hair thinning.